Corcept Therapeutics Achieves Significant Milestone In Ovarian Cancer Treatment
$CORT
Corcept Therapeutics (NASDAQ:CORT) has recently announced a breakthrough in the treatment of platinum-resistant ovarian cancer, marking a significant advancement in the field of oncology. The company’s latest Phase 3 trial, known as ROSELLA, met its primary endpoint, showcasing the efficacy of its drug, relacorilant, in combination with nab-paclitaxel. The trial results demonstrated a 30% reduction in the risk of disease progression compared to patients treated with nab-paclitaxel alone.
This improvement in progression-free survival (PFS) was statistically significant, with a hazard ratio of 0.70 and a p-value of 0.008. Furthermore, an interim evaluation of overall survival (OS) revealed a notable enhancement, with patients treated with the combination therapy experiencing a median OS of 16.0 months, compared to 11.5 months for those receiving the standard treatment.
Relacorilant, an oral therapy, functions by selectively antagonizing the glucocorticoid receptor (GR), which plays a crucial role in modulating the effects of cortisol. By blocking cortisol activity, relacorilant helps to counteract the resistance mechanisms of tumors against chemotherapy. This mechanism of action not only enhances the efficacy of chemotherapy but also maintains a favorable safety profile, as no new safety concerns were observed during the trial.
The success of the ROSELLA trial is particularly significant for patients with platinum-resistant ovarian cancer, a challenging condition where the cancer does not respond to conventional platinum-based chemotherapy. Currently, treatment options for these patients are limited and the prognosis is typically poor. The introduction of relacorilant could potentially transform the therapeutic landscape for these patients, offering a new line of defense against this aggressive form of cancer.
The trial’s positive outcome is expected to support a New Drug Application (NDA) in the United States and a Marketing Authorization Application (MAA) in Europe. Corcept plans to present the complete results at an upcoming medical conference and anticipates submitting the NDA in the third quarter of the year.
For over 25 years, the company has been at the forefront of research in severe endocrinologic, oncologic, metabolic and neurologic disorders, continually expanding its portfolio of proprietary selective cortisol modulators and GR antagonists. The successful results from the ROSELLA trial represent a pivotal moment for Corcept Therapeutics and for the field of oncology. The company moves forward with regulatory submissions, the healthcare community eagerly anticipates the potential impact of relacorilant on improving the lives of patients battling platinum-resistant ovarian cancer.
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